Everton take on Manchester United in Monday afternoon’s Premier League clash at Goodison Park (kick-off 5.30pm GMT).
United have a number of injuries to contend with in their squad leading to Jose Mourinho making a number of changes.
Rashford was expected to come in and lead the line after coming on to replace Lukaku at the weekend.
But Mourinho has opted to give Martial a rare opportunity down the middle, with the England international on the bench.
Marcos Rojo, Ander Herrera are the other two changes for United as Ashley Young and Henrikh Mkhitaryan are replaced.
Manchester United starting line-up: De Gea, Lindelof, Jones, Rojo, Shaw, Matic, Herrera, Mata, Pogba, Lingard, Martial
Subs: Romero, Blind, Darmian, Smalling, Tuanzebe, Mkhitaryan, Rashford
Everton starting line-up: Pickford, Schneiderlin, Keane, Williams, Bolasie, Rooney, Martina, Niasse, Davies, Vlasic, Holgate
Subs: Robles, Jagielka, Lennon, McCarthy, Sigurdsson, Calvert-Lewin, Kenny
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